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KMID : 0377619720220040435
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Korean Jungang Medical Journal
1972 Volume.22 No. 4 p.435 ~ p.440
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Effects of Chlorpromazine, Meprobamate and Chlordiazepoxide on the Maze Learning in Mice
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Abstract
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In order to assess the effect of the tranquilizers, i.e. Chlorpromazine, mepro,bamate and chlordiazep oxide on maze learning, mice were tested in a single- T water maze after one of the following drug treatments; physiological saline; .1.25mg/kg of chlorpromazine; 20mg/kg of meprobamate; and 10mg/kg of chlordiazepoxide.
The test apparatus was a galvanized steel T-tank 11. 5cm wide and 18cm -deep described by Latz et al. (1967). The maze was filled with 22-24°C water to a depth of 10cm. Drugs were administrated intraperitoneally 20-30min. before test. A session consisted of 3 adaptation and consecutive 20 test trials. The number of correct trials and swimming speed were served as an index of learning performances.
The results obtained were as follows;
As compared to physiological saline, the number of correct trials were significantly decreased and the swimming speed was significantly delayed after administration of chlorpromazine, but the number of successful trials and swimming time were not changed significantly after administration of mepro bamate and chlordiazepoxide.
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